Comparison of Threshold-Based Segmentation Methods on Pre- and Post-Therapy PET Scans
نویسندگان
چکیده
The aim of this study was to compare several threshold-based segmentation methods in delineating tumours on preand posttherapy PET scans both in terms of the volumes segmented and the effect on predicting survival. On a dataset of 14 patients with mesothelioma, different segmentation methods were found to correlate well with each other for preand posttherapy tumour volume (TV) and total lesion glycolysis (TLG) but did not correlated as well for absolute change and % change of TV and TLG between preand posttherapy images. This was also found for the effect of the TV and TLG on receiver operator characteristics (ROC) analysis on 6month progression free survival (PFS) in where the segmentation method had little effect when assessing preor posttherapy TV and TLG but showed significant differences when using change of % change as a predictor of PFS.
منابع مشابه
Contribution of 68Ga-PSMA PET/CT to targeting volume delineation of prostate cancer treated with conformal radiation therapy: Which SUV threshold is appropriate?
Introduction: Prostate-specific membrane antigen (PSMA) has been demonstrated as a promising tool for specific imaging of prostate cancer (PCa) via positron emission tomography-computed tomography (PET/CT) scanning. Radiation treatment planning (RTP) based on 68Ga-PSMA PET/CT scanning can also lead to some decision modifications. The specific goal o...
متن کاملComparing 511 keV Attenuation Maps Obtained from Different Energy Mapping Methods for CT Based Attenuation Correction of PET Data
Introduction: The advent of dual-modality PET/CT scanners has revolutionized clinical oncology by improving lesion localization and facilitating treatment planning for radiotherapy. In addition, the use of CT images for CT-based attenuation correction (CTAC) decreases the overall scanning time and creates a noise-free attenuation map (6map). CTAC methods include scaling, s...
متن کاملThe potential value of F-18 FDG PET in comparison to ct in early prediction of response to Imatinib (STI571) therapy in patients with gastrointestinal stromal tumors
Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GIST has been shown to over-express c-KIT (CD117), the receptor tyrosine kinase. Imatinib (STI571 or Glivec) is a new type of tyrosine kinase inhibitor that selectively inhibits various tyrosine kinases and has been successfully used to trea...
متن کاملChanging Therapeutic Paradigms: Predicting mCRC Lesion Response to Selective Internal Radionuclide Therapy (SIRT) based on Critical Absorbed Dose Thresholds: A Case Study
A 65 year old male with metastatic colorectal cancer (mCRC) in the liver was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy. 90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion dosimetry was highly predictive of eventual response in ...
متن کاملComparison of state-of-the-art atlas-based bone segmentation approaches from brain MR images for MR-only radiation planning and PET/MR attenuation correction
Introduction: Magnetic Resonance (MR) imaging has emerged as a valuable tool in radiation treatment (RT) planning as well as Positron Emission Tomography (PET) imaging owing to its superior soft-tissue contrast. Due to the fact that there is no direct transformation from voxel intensity in MR images into electron density, itchr('39')s crucial to generate a pseudo-CT (Computed Tomography) image ...
متن کامل